School of Pure and Applied Sciences
https://karuspace.karu.ac.ke/handle/20.500.12092/1952
Thu, 14 Nov 2019 06:55:33 GMT2019-11-14T06:55:33ZAnti-Pyretic Properties of Methanolic Bark Extracts of Terminalia brownii in Wistar Rats (Rattus novegicus)
https://karuspace.karu.ac.ke/handle/20.500.12092/2351
Anti-Pyretic Properties of Methanolic Bark Extracts of Terminalia brownii in Wistar Rats (Rattus novegicus)
Mbinda, Wilton; Kasili, Sichangi; Mbiri, Jane W; Kisangau, Patrick D; Piero, Ngugi M
The conventional drugs used to manage fever are usually not affordable, not easily available and have adverse side effects. Alternative therapeutic agents, like medicinal plant derivatives, should therefore be developed because they have been reported to be more affordable, more readily available and have lesser side effects. Terminalia brownii is traditionally used to manage fever but this ethno-medicinal claim lacks scientific validation. The present study therefore evaluated the anti-pyretic activity of T. brownii in Wistar rats. Fresh bark samples of T. brownii were collected from Kitui County, Kenya. This study used 30 adult male Wister rats that were 2-3 months old and weighing 140-180 g was used for the experiments. Steam-distilled turpentine was the pyrogen used to induce pyrexia and Aspirin was used as the reference drug. The extract reduced the elevated rectal temperatures by between 1.15- 4.38% while aspirin reduced the elevated rectal temperatures by between 0.00-4.85%. The present study showed a significant dose-dependent anti-pyretic activity of methanolic bark extracts of T. brownii hence validating its folklore use as a fever remedy.
DOI: 10.4172/2472-0992.100012
Fri, 01 Jan 2016 00:00:00 GMThttps://karuspace.karu.ac.ke/handle/20.500.12092/23512016-01-01T00:00:00ZD-Optimal Designs for Third-Degree Kronecker Model Mixture Experiments with an Application to Artificial Sweetener Experiment
https://karuspace.karu.ac.ke/handle/20.500.12092/2345
D-Optimal Designs for Third-Degree Kronecker Model Mixture Experiments with an Application to Artificial Sweetener Experiment
Kinyanyui, Josphat; Kungu, Peter; Ronoh, Benard; Korir, Betty; rutto, Mike; Koske, Joseph; Kerich, Gregory
This study investigates some optimal designs in the third degree Kronecker model mixture experiments for non-maximal subsystem of parameters, where Kieferâ€™s functions serve as optimality criteria. Based on the completeness result, the considerations are restricted to weighted centroid designs. First, the coefficient matrix and the associated parameter subsystem of interest using the unit vectors and a characterization of the feasible weighted centroid design for a maximal parameter subsystem is obtained. Once the coefficient matrix is obtained, the information matrices associated with the parameter subsystem of interest are generated for the corresponding factors. We apply the optimality criteria to evaluate the designs.
Wed, 01 Jan 2014 00:00:00 GMThttps://karuspace.karu.ac.ke/handle/20.500.12092/23452014-01-01T00:00:00ZValidation of Popular Models used in the Analysis of Specific Activities of Primordial Radionuclides in Environmemtal Samples trough 1-D Analytical Modeling.
https://karuspace.karu.ac.ke/handle/20.500.12092/2339
Validation of Popular Models used in the Analysis of Specific Activities of Primordial Radionuclides in Environmemtal Samples trough 1-D Analytical Modeling.
Kebwaro, J. M.; Chege, M. W.
Tue, 01 Jan 2019 00:00:00 GMThttps://karuspace.karu.ac.ke/handle/20.500.12092/23392019-01-01T00:00:00ZAn Introduction to Differential Geometry: The Theory of Surfaces
https://karuspace.karu.ac.ke/handle/20.500.12092/2338
An Introduction to Differential Geometry: The Theory of Surfaces
Gikonyo, Kuria Joseph; Kinyua, Kande Dickson
From a mathematical perspective, a surface is a generalization of a plane which does not necessarily require being flat, that is, the curvature is not necessarily zero. Often, a surface is defined by equations that are satisfied by some coordinates of its points. A surface may also be defined as the image, in some space of dimensions at least three, of a continuous function of two variables (some further conditions are required to insure that the image is not a curve). In this case, one says that one has a parametric surface, which is parametrized by these two variables, called parameters. Parametric equations of surfaces are often irregular at some points. This is formalized by the concept of manifold: in the context of manifolds, typically in topology and differential geometry, a surface is a manifold of dimension two; this means that a surface is a topological space such that every point has a neighborhood which is homeomorphic to an open subset of the Euclidean plane. A parametric surface is the image of an open subset of the Euclidean plane by a continuous function, in a topological space, generally a Euclidean space of dimension at least three. The paper aims at giving an introduction to the theory of surfaces from differential geometry perspective.
Sun, 01 Jan 2017 00:00:00 GMThttps://karuspace.karu.ac.ke/handle/20.500.12092/23382017-01-01T00:00:00Z