Anti-Pyretic Properties of Methanolic Bark Extracts of Terminalia brownii in Wistar Rats ( Rattus novegicus )

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Date

2016

Authors

Mbinda, Wilton
Kasili, Sichangi
Mbiri, Jane W
Kisangau, Patrick D
Piero, Ngugi M

Journal Title

Journal ISSN

Volume Title

Publisher

J Pharmacogn Nat Prod, an open access journal

Abstract

The conventional drugs used to manage fever are usually not affordable, not easily available and have adverse side effects. Alternative therapeutic agents, like medicinal plant derivatives, should therefore be developed because they have been reported to be more affordable, more readily available and have lesser side effects. Terminalia brownii is traditionally used to manage fever but this ethno-medicinal claim lacks scientific validation. The present study therefore evaluated the anti-pyretic activity of T. brownii in Wistar rats. Fresh bark samples of T. brownii were collected from Kitui County, Kenya. This study used 30 adult male Wister rats that were 2-3 months old and weighing 140-180 g was used for the experiments. Steam-distilled turpentine was the pyrogen used to induce pyrexia and Aspirin was used as the reference drug. The extract reduced the elevated rectal temperatures by between 1.154.38% while aspirin reduced the elevated rectal temperatures by between 0.00-4.85%. The present study showed a significant dose-dependent anti-pyretic activity of methanolic bark extracts of T. brownii hence validating its folklore use as a fever remedy.

Description

DOI: 10.4172/2472-0992.1000121

Keywords

Anti-pyretic activity, Aspirin, Methanolic bark extracts, Terminalia brownii

Citation

J Pharmacogn Nat Prod, an open access journal, Volume 2 • Issue 3 • 1000121

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